*United States Patent
*Licensed Under Patent #       5,629,286
*Date of Patent                           May 13, 1997
*Inventor                                      Dr. Barbara Brewitt, Ph.D.

Homeopathic human growth hormone(HhGH) is an anti-aging breakthrough in natural medicine.  A safe, non-toxic tablet for oral administration by today’s consumer, this product takes the hGH profile of expensive pharmaceutical human growth hormone (hGH) and makes it easy to obtain and use safely by the person taking responsibility for their health.  Homeopathic HhGH offers a way to enhance immune responsiveness*, increase lean body mass and stimulate neuroendocrine system balance and optimal physical and mental performance.  These tablets contain actual recombinant human growth hormone.

Growth Factors such as Insulin-like Growth Factor (IGF1) are small proteins produced by the human body that enable cells to communicate and effectively coordinate activities between one another.  Growth factors:

• Regulate cell growth, division and specialization
• Coordinate immune, nervous and hormonal systems
• Enhance cell communication
• Compete with viruses for expression of the same genetic sites
• Dr. Brewitt measured 9-24% increases in serum IGF1 within the first month of oral administration of homeopathic hGH and 8-14% increases in numbers of total lymphocytes, T-lymphocytes, CD4 and CD8 lymphocytes in the first two weeks of homeopathic hGH use by healthy persons.  Additionally, participants in this preliminary study had relief from joint pain, dry skin and night sweats.

Growth Hormone’s Positive Effects are:

• Increase lean body mass with and without exercise
• Stimulate regrowth of heart, liver, spleen, kidneys and other organs that shrink with age – Great anti-aging benefit
• Burn fat and protect current protein stores while building greater protein reserves.
• Improve energy levels and heighten exercise performance.
• Improve immune function
• Provide better kidney function
• Build stronger bones
• Generate greater cardiac output
• Lower blood pressure
• Improve cholesterol by lowering LDLs and sometimes raising HDL
• Assisting with sharper vision
• Assisting with increased memory
• Increasing general sense of well being including greater sexual performance
• Assisting to speed wound healing
• Improves skin condition
• Some people have reported hair regrowth

Now, T2000 Gold’s HhGH and HIGF1, a new class of medicines, combine today’s advanced biotechnology’s modern molecular biology, and basic homeopathic principles to help people achieve a greater sense of physical and mental balance.

Homeopathic Human Growth Hormone and Growth Factors are available in tablet form for your customers by the patented process invented by Dr. Barbara Brewitt, formerly with the National Institutes of Health.

Groundbreaking research by Dr. Brewitt is being done on these products for both chronic and acute conditions.

HOMEOPATHY

Homeostasis
Health is represented by dynamic fluxes of energy, also recognized as homeostasis.  True homeostasis or health is defined as optimal mental and physical well being while maintaining a dynamic equilibrium.  When the body loses its normal homeostasis, adverse symptoms appear.  Symptoms are not the cause of health problems, but rather an expression of the body’s efforts to defend its weakest areas and bring the body back into homeostasis (balance).  When functioning in a balanced state, the body sustains healthy homeostasis and effectively compensates for stress factors, such as germs, fatigue, nutritional deficiencies, weight loss or excessive weight gain, and/or emotional stress.  Under healthy homeostasis conditions, the body heals itself when trauma or stress occurs.  However, with continued stress or trauma, the body works harder to adapt to these extraneous conditions, therefore, depleting energy reserves.  Chronic depletion of reserves leads to slower response times to stress factors, with consequential unregulated energy fluctuations.  Thus, with a chronically exhausted body, homeostasis is lost, giving rise to disease through ineffective immune, nervous, and metabolic system responses to stress factors.

Once these weak areas are identified and supported, the body automatically returns to a healthy homeostasis.  Health is re-established when the actual cause of the health problem is identified and key organs or tissues are supported back to their natural strength.  This is often in contrast to merely treating or suppressing the obvious symptoms through the use of drugs, whose hGH concentrations sometimes have harmful side effects.

History of Homeopathy
Developed more than 200 years ago, homeopathy is a natural form of medicine, which uses immeasurably small doses of medicines to stimulate the body’s own defense and healing process.  Concerned with treating the whole person, homeopathy focuses on bringing the entire body back into homeostasis.

In the late 1700’s, German physician Samuel Hahnemann developed the principle of the Law of Similar, or “Let Like Cure Like”.  Today, the Law remains a defining principle of homeopathy.  If a substance causes side effects and syndromes at high toxic levels in people, this same substance can heal these same symptoms and syndromes when given in small-diluted doses. Similar to a vaccine, these small doses work by stimulating the body’s own defense mechanisms.  The “Characteristics and Guiding Symptoms” sheet developed by Dr. Barbara Brewitt provides a profile of symptoms collected from the medical literature about the adverse effects produced by hGH concentrations of a growth 
factor, or the symptoms reported as treatable from people using that same growth factor at a homeopathic dilution or very low concentration.  Careful matching between the
known symptoms of the targeted condition and the adverse side effect symptoms produced by pharmacological doses of growth factors leads to curative effects when the growth factor is given homeopathically.
 

Human Growth Hormone and Growth Factors
Growth factors are well known for their different regulatory roles in the body.  Regulatory function differs depending on the condition and type of cell, the presence of different hormones and proteins, and any additional stress factors affecting tissue integrity.  The descriptions are based on the general regulatory roles of these growth factors in the body and the known mechanisms of action.  As a hormone, human growth hormone affects specific target tissues in its role as a chemical messenger.  Human growth hormone works with Insulin-like growth factor to affect uptake of nutrients into the cell.

Growth factors are small proteins produced within the body to facilitate cell communication and maintain healthy homeostasis.  Growth factors have significant effects on DNA, RNA, protein synthesis, and cell division.  It has been determined that growth factors in the body affect the individual cells by binding to growth-factor-specific receptors on the cell’s surface.  Receptor binding initiates a sequence of events inside the cell, leading to the cell nucleus where the required action takes place through its effects on DNA synthesis.  The signal from a growth factor affects the cell cycle through positive and negative feedback processes, and may be involved in controlling various cell functions.

IGF1 (Insulin-like Growth Factor)
IGF1 is primarily secreted by the liver in response to a signal from growth hormone (hGH).  It is also released by many different tissues throughout the body and affects almost every cell to some degree.  The major target tissues affected by IGF1 are muscle, cartilage, bone, liver, kidney, nerves, skin, and lungs.  IGF1 additionally regulates cell growth by moving cells from a resting phase to an active phase of the cell cycle.  Because of these actions, IGF1 is known as a ‘progression’ factor.  Progression factors induce cells toward a ‘starting line’ for cell division and often that is all cells need for successful activation.  IGF1 also cooperates with PDGF to increase the cell’s ability to complete DNA synthesis.  IGF1 not only helps cell growth by division, but also by enhancing cell specialization.  Hormonal functions such as the anabolic (constructive) activity of hGH depends on the production and presence of IGF1 to achieve positive results.

IGF1 increases physical performance, mental performance and physical endurance in healthy individuals.  It communicates an anabolic signal to cells, regulating cell division and differentiation as the muscle acquires an increased need for strength or as injury to the muscle is incurred.  Additionally, IGF1 promotes the growth of muscle and bone.  Studies show that after a one-week period of strenuous exercise, blood levels of IGF1 are significantly increased due to either regenerative processes from muscle injury or higher requirements in muscles to handle the weight load. IGF1 acts within the nervous system and is critical for the growth and development of nerve cells.  IGF1 plays an active role at the neuromuscular junction, where the cooperation between the nerve and muscle cells takes place.

In aging cells, there is a greater need for more IGF1 in order to move cells out of the ‘resting phase’ and into a growth phase of the cell cycle.  A slower growth of cells during the aging process correlates with a higher requirement of IGF1 than the body supplies. The increase in cellular communication from an addition of IGF1 may bring the aging slower cells back into the balanced state optimizing cell activity and tissue/organ performance. The pivotal role growth factors play in maintaining healthy homeostasis spurred considerable research among leading biotech and pharmaceutical companies during the 1980’s.  But enthusiasm dimmed in the early 1990’s as clinical studies revealed that high concentrations of growth factors tested in clinical studies had toxic and unacceptable adverse side effects.  Today growth factors are being used and tested by pharmaceutical companies in pharmacological doses despite many undesirable side effects.  Growth factor therapy requires a prescription from a primary care physician, is only delivered via injection and usually costs a patient $80 - $250 per day.  An exciting alternative to this conventional approach is the safe, homeopathic approach using an oral delivery that can cost only $1 - $2 per day.

Growth Hormone
Growth hormone is a 191 amino acid protein molecule that falls into the class of hormones, yet has specific structural and signaling features similar to growth factors.  Structural binding of growth hormone to its receptor is highly specific and complex, thus a single amino acid substitution in the growth hormone molecule can be sufficient to interfere with growth hormones ability to transmit its signal through its receptor.  Unlike growth factors that work on many cells and tissues throughout the body, growth hormone has a primary target tissue, the liver, for its action.  Growth hormone is secreted from the pituitary gland in pulses (somewhere between 9-29 pulses/24 hours) during the late afternoon and early hours of sleep.  Growth hormone binds to a binding protein and is then carried in the bloodstream to the liver where it stimulates the synthesis of insulin-like growth factor-1 (IGF1).  It is IGF1 that carries out most of the anabolic effects of growth hormone.  Hormones are very important proteins with respect to life giving processes throughout the body since they maintain emotional, hormonal and nervous system harmony.  Growth hormone is particularly more powerful throughout the body for a broad spectrum of symptoms related to feeling “young” and “robust” because of its team efforts with IGF1.
 

Human Growth Hormone and IGF1
Effects on the Aging Body
As the body ages, cells, tissues and whole systems do not perform as well as they once did.  In an effort to reverse these changes, or simply treat the symptoms, the aging population searches for a solution, from vitamins to herbal supplements to hormone treatments, but at what cost?

Homeopathy, a traditional form of medicine dating back two hundred years, may be the answer.  Founded on basic principles of pharmacology, homeopathy gently promotes the positive effects of supplements or drugs, while at the same time reducing adverse side effects due to hGH concentrations.  Using hormonal supplementation in a homeopathic dilution may be the solution to promoting anti-aging benefits in a safe, gentle manner.

Human Growth Hormone (hGH) and its mediator, insulin-like growth factor-1 (IGF1) may actually help treat the blueprint of aging, keeping the cells in as healthy a state as possible.  The cells ability to function depends on the genetic codes for all the proteins, hormones, and enzymes that make the cell run.  Up until now, one of the few ways we could limit the damage to the DNA was to take antioxidant supplements such as Vitamin C and E to bolster our own defenses.  But human growth hormone and IGF1 go further and do what antioxidants cannot do.  hGH and IGF1 help the DNA repair itself better prior to cell division.  Human growth hormone initiates the transport of amino acids and nucleic acids into the cell, including the cell membranes.  IGF1 facilitates the transport of nucleic acids into the nucleus of the cell where the DNA resides, giving it the raw material needed to repair damage to the DNA and initiate cell division.

Human growth hormone (hGH) is responsible for many effects on growth, development, immunity and metabolism, especially in terms of aging.  Produced and secreted by the anterior pituitary gland in the brain, hGH is released in pulses in response to signals from the hypothalamus.  hGH exerts anabolic effects throughout the body, favoring growth of tissues, bones and muscles.  Studies have shown that the aging population exhibits lowering levels of growth hormone in the body, with significant effects on lean body mass, fat deposits, immunity, and overall energy.

See diagram of hypothalamus

While hGH supplementation has many benefits, the hGH concentrations commonly prescribed or long term repeated use might have adverse side effects such as joint pain and stiffness, carpal tunnel syndrome, fluid retention, weakness and fatigue.  These effects may be due to receptor overload, when the cells receptors become saturated with a certain molecule.  When overloaded in this manner, the cell may shut down, and cease to respond, thus the positive effects are lost.  This situation may be avoided when the dose of human growth hormone is very low, such as in a homeopathic medicine.  The homeopathic doses of hGH may alleviate adverse effects caused by high doses of hGH, while at the same time gently stimulate the body to promote the known benefits of hGH.  Founded on the belief the body reacts to drugs with both negative and positive reactions, homeopathy uses serially diluted forms of medicines to reduce negative reactions and maintain the positive benefits of the medicine.

The effects of hGH on human growth and development are mediated by the local production of IGF1.  Growth hormone and IGF1 directly control bone and muscle growth.  They can increase muscle mass while lowering body fat, raising hGH-density lipoprotein (HDL, the good cholesterol) and lessening low-density lipoprotein (LDL, the bad cholesterol); they can also increase bone density 10 percent to 15 percent in the first two years of use.  Through its effects on IGF1, hGH can promote the uptake of amino acids by muscle cells, stimulating muscle growth. hGH has also been found to promote protein retention and improve protein balance in a variety of conditions, including burn and surgical postoperative patients.

Aging is accompanied by a decrease in hGH secretion and consequently, decreased IGF1 production.  The decrease in hGH levels seen with aging may result in detrimental health consequences such as reduced skeletal muscle mass and strength, decreased bone density, increased fat and reduced exercise capacity.  The effects of human aging on hGH secretion have been evaluated in a number of studies, indicating an age-related decline in serum concentrations.  hGH, along with other regulatory hormones, regulates bone remodeling and influences the formation and/or activation of growth factors, which are synthesized in the bone and may be stored in the matrix.  Growth hormone is active in bone matrix development, suggesting a role in preservation of bone mass.  Growth hormone deficiency in the elderly may therefore be a significant contributor to osteoporosis.

Normal aging is characterized by changes in body composition that include decreases in bone and muscle mass and an increase in adiposity.  Studies demonstrate that by age 70-80, 53% of adult subjects had no significant hGH detectable during a 24-hour period, classifying them as hGH deficient.  It has also been demonstrated that although hGH response is diminished, elderly men and women retain their responsiveness to hGH-releasing hormone, suggesting a hypothamic defect as a cause for the age-related decline in hGH release.  A study evaluating the effect of recombinant human (rh) hGH and rhIGF1 on the metabolic status of elderly women resulted in significant effects on protein balance and body composition.  Both hGH and IGF1 stimulated a significant loss of fat mass after 4 weeks of treatment, and significant increases in lean body mass and protein retention.

Aging decreases immune function, apparently due to the age-related decline in the regulatory control of the immune system.  Some of this decline is due to intrinsic changes within the lymphocyte populations, but some of the decline may be due to extrinsic factors, such as hormones, growth factors and nutrients.  hGH has been shown to stimulate phagocytesis in vitro by neutrophils from elderly adults, and hGH administration to elderly men restored natural killer cell function to that of healthy young adults.  An aging primate model suggests that hGH and IGF1 administration stimulated antibody responses to tetanus toxoid in vivo.  Studies of patients with hGH deficiency clearly indicate that both HGH and IGF1 can alter immune function.  Lymphocytes, which are the cells most affected by the aging process, are also the cells most responsive to hGH/IGF1.  Thus hGH deficiency may be an important factor in the decline of immune function in the elderly.

The involution of the thymus is also considered an age-related change.  An involuted thymus cannot support optimal T lymphocyte cell maturation and had been implicated in the poor immune reconstitution of adults compared to that in children.  Therefore, during later years, there is a decline in the number of T cells moving through the thymus into secondary lymphoid organs, leading to a decrease in naïve T cells and an increase of memory T cells.  Poor T lymphocyte cell function may cause immune dysfunction in the elderly, with an associated increase in infectious disease incidence and an increase in mortality due to infectious illness.  At present, there are no accepted methods for the maintenance or reconstitution of the immune response in the elderly.  Studies in rodents show IGF1 and hGH significantly impact the immune system.  A recent study evaluated the effect of a seven-week administration of rhhGH and rhIGF1 given individually on immune function in elderly female rhesus monkeys.  Results demonstrated that immune function in non-human primates was stimulated by rhhGH and rhIGF1 and suggested a causal relationship between hGH and IGF1 and age-related immune dysfunction as well as a clinical role for IGF1 in states of immune compromise.  Both hGH and IGF1 given independently, have significant effects on the immune system.

With many positive effects on the body, supplementation with human growth hormone may be a significant factor in treating symptoms of aging.  Homeopathic dilutions of human growth hormone promote these benefits without the adverse side effects associated with previous hGH dose forms of growth hormone.

Homeopathic IGF1 works in many different areas of the body to facilitate and improve cellular performance.  A recent independent double blind, placebo-controlled clinical testing of homeopathic IGF1 demonstrated effectiveness in the nervous, reproductive, musculo/skeletal, and gastrointestinal systems.  Specifically, homeopathic IGF1 improved energy levels, respiratory conditions, PMS and menopause.  It also relieved muscle and bone aches and pains, joint stiffness, intestinal difficulties and improved mental concentration and clarity.  Increases in lean body mass also have been anecdotally reported.  Homeopathic IGF1 balances weight, helping the body to achieve its natural optimum weight, whether that means losing weight for people too heavy or gaining weight for people too lean.  A double-blind placebo study found homeopathic IGF1 to be effective in alleviating inflammation in the body, and other anecdotal benefits are being clinically evaluate.
 

GUIDE TO MAXIMIZING THE EFFECTIVENESS OF RECOMBINANT hGH AND IGF-1

Suggested use guideline: 
Directions For Healthy Individuals:

• hGH

First 2 months
1 tablet three times daily:  after rising, between 3-5PM and before going to sleep.  After 2 months, cycle off for 1 week and then repeat the original 2-month regimen.

• IGF-1

1 tablet three times daily: after rising, between 3-5PM and before going to sleep.  IGF-1 should be taken prior to taking hGH, allowing approximately 30 seconds between tablets to maximize the absorption and cell signaling of each product.  IGF-1 should be taken regularly with no need for cycling on and off.

GENERAL INSTRUCTIONS FOR HOMEOPATHIC PRODUCTS:
Place the tablet on your tongue and chew, and then swish the product in your mouth for maximum cell signaling.  Use only water for at least 30 minutes before and after taking the products.  Multi-minerals taken in the evening can maximize cell responsiveness to the signaling.  Drink lots of clean water to carry away body pollutant
.
STORAGE AND HANDLING:
Keep products tightly capped in their original containers.  These products may pass through airport security without problems.  Store products out of direct sunlight and away from mentholated lotions and ointments. Products should be maintained in a controlled climate ranging from50 to 90 degrees F (10-30 degrees C).  Please do not freeze.